Subcritical Water Hydrolysis Effectively Reduces the In Vitro Seeding Activity of PrP^Sc but Fails to Inactivate the Infectivity of Bovine Spongiform Encephalopathy Prions

• Yuichi Murayama ,

  * E-mail: ymura@affrc.go.jp

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Miyako Yoshioka,

  Affiliations Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan, Research Area of Pathology and Pathophysiology, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Hiroyuki Okada,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Eri Takata,

  Affiliations Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Fukuoka, Japan, Forestry and Forest Products Research Institute, Tsukuba, Ibaraki, Japan

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• Kentaro Masujin,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Yoshifumi Iwamaru,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Noriko Shimozaki,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Tomoaki Yamamura,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Takashi Yokoyama,

  Affiliation Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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• Shirou Mohri,

  Affiliations Influenza/Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan, Department of Neurological Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

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• Yuji Tsutsumi

  Affiliation Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Fukuoka, Japan

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