Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Michael S. Boosalis; Jose I. Sangerman; Gary L. White; Roman F. Wolf; Ling Shen; Yan Dai; Emily White; Levi H. Makala; Biaoru Li; Betty S. Pace; Mehdi Nouraie; Douglas V. Faller; Susan P. Perrine

doi:10.1371/journal.pone.0144660

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Peer-reviewed

Research Article

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Michael S. Boosalis,

Affiliation Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Jose I. Sangerman,

Affiliation Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Gary L. White,

Affiliation Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Roman F. Wolf,

Affiliation Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Ling Shen,

Affiliation Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Yan Dai,

Affiliation Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Emily White,

Affiliation Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Levi H. Makala,

Affiliation Department of Pediatrics, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Biaoru Li,

Affiliation Department of Pediatrics, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Betty S. Pace,

Affiliation Department of Pediatrics, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Mehdi Nouraie,

Affiliation Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, DC, United States of America
⨯
Douglas V. Faller,

Affiliations Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America, Phoenicia BioSciences, Weston, Massachusetts, United States of America
⨯
Susan P. Perrine

* E-mail: sperrine@bu.edu

Affiliations Cancer Center and Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America, Phoenicia BioSciences, Weston, Massachusetts, United States of America
⨯

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Michael S. Boosalis,
Jose I. Sangerman,
Gary L. White,
Roman F. Wolf,
Ling Shen,
Yan Dai,
Emily White,
Levi H. Makala,
Biaoru Li,
Betty S. Pace

Published: December 29, 2015
https://doi.org/10.1371/journal.pone.0144660

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