An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa; Satomi Tanaka; Fumihiro Fujiki; Soyoko Morimoto; Hiroko Nakajima; Naoya Tatsumi; Jun Nakata; Satoshi Takashima; Sumiyuki Nishida; Akihiro Tsuboi; Yoshihiro Oka; Yusuke Oji; Atsushi Kumanogoh; Haruo Sugiyama; Naoki Hosen

doi:10.1371/journal.pone.0144594

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Peer-reviewed

Research Article

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa,

Affiliations Department of Cancer Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Satomi Tanaka,

Affiliation Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Fumihiro Fujiki,

Affiliation Department of Cancer Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Soyoko Morimoto,

Affiliation Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Hiroko Nakajima,

Affiliation Department of Cancer Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Naoya Tatsumi,

Affiliation Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Jun Nakata,

Affiliation Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Satoshi Takashima,

Affiliation Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Sumiyuki Nishida,

Affiliation Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Akihiro Tsuboi,

Affiliation Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Yoshihiro Oka,

Affiliations Department of Cancer Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Immunopathology, WP1 Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
⨯
Yusuke Oji,

Affiliation Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Atsushi Kumanogoh,

Affiliations Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Immunopathology, WP1 Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
⨯
Haruo Sugiyama,

Affiliation Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Naoki Hosen

* E-mail: hnaoki@imed3.med.osaka-u.ac.jp

Affiliation Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa,
Satomi Tanaka,
Fumihiro Fujiki,
Soyoko Morimoto,
Hiroko Nakajima,
Naoya Tatsumi,
Jun Nakata,
Satoshi Takashima,
Sumiyuki Nishida,
Akihiro Tsuboi

Published: December 11, 2015
https://doi.org/10.1371/journal.pone.0144594

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