Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

Giampiero Porcu; Eliseo Serone; Velia De Nardis; Daniele Di Giandomenico; Giuseppe Lucisano; Marco Scardapane; Anna Poma; Antonella Ragnini-Wilson

doi:10.1371/journal.pone.0144550

Loading metrics

Open Access

Peer-reviewed

Research Article

Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

Giampiero Porcu ,

Contributed equally to this work with: Giampiero Porcu, Eliseo Serone

Affiliations Department of Biology, University of Rome "Tor Vergata", Rome, Italy, Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy
⨯
Eliseo Serone ,

Contributed equally to this work with: Giampiero Porcu, Eliseo Serone

Affiliations Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy, Department of Life, Health and Environmental Sciences, University of L'Aquila, L’Aquila, Italy
⨯
Velia De Nardis,

Affiliation Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy
⨯
Daniele Di Giandomenico,

Affiliation Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy
⨯
Giuseppe Lucisano,

Affiliations Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy, Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, Università di Bari Aldo Moro, Bari, Italy
⨯
Marco Scardapane,

Affiliations Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy
⨯
Anna Poma,

Affiliation Department of Life, Health and Environmental Sciences, University of L'Aquila, L’Aquila, Italy
⨯
Antonella Ragnini-Wilson

* E-mail: antonella.ragnini@uniroma2.it

Affiliations Department of Biology, University of Rome "Tor Vergata", Rome, Italy, Department of Translational Pharmacology, Fondazione Mario Negri Sud, S. Maria Imbaro (CH), Italy
⨯

Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

Giampiero Porcu,
Eliseo Serone,
Velia De Nardis,
Daniele Di Giandomenico,
Giuseppe Lucisano,
Marco Scardapane,
Anna Poma,
Antonella Ragnini-Wilson

Published: December 10, 2015
https://doi.org/10.1371/journal.pone.0144550

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Multiple sclerosis
Is the Subject Area "Multiple sclerosis" applicable to this article?

Thanks for your feedback.
Library screening
Is the Subject Area "Library screening" applicable to this article?

Thanks for your feedback.
Reverse transcriptase-polymerase chain reaction
Is the Subject Area "Reverse transcriptase-polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Glucocorticoid therapy
Is the Subject Area "Glucocorticoid therapy" applicable to this article?

Thanks for your feedback.
Statistical data
Is the Subject Area "Statistical data" applicable to this article?

Thanks for your feedback.