Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

• Linlin Chang ,

  Contributed equally to this work with: Linlin Chang, Xiaowen Liu

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Xiaowen Liu ,

  Contributed equally to this work with: Linlin Chang, Xiaowen Liu

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Dandan Wang,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Jian Ma,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Tianyi Zhou,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Ying Chen,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Rong Sheng,

  Affiliation ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Yongzhou Hu,

  Affiliation ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Ying Du,

  Affiliation Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

  ⨯
• Qiaojun He,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Bo Yang,

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯
• Hong Zhu

  * E-mail: hongzhu@zju.edu.cn

  Affiliation Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

  ⨯