Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers

Martin Kächele; Anita M. Hennige; Jürgen Machann; Anja Hieronimus; Apostolia Lamprinou; Fausto Machicao; Fritz Schick; Andreas Fritsche; Norbert Stefan; Bernd Nürnberg; Hans-Ulrich Häring; Harald Staiger

doi:10.1371/journal.pone.0144494

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Research Article

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers

Martin Kächele,

Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
⨯
Anita M. Hennige,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
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Jürgen Machann,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany, Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, University Hospital Tübingen, Tübingen, Germany
⨯
Anja Hieronimus,

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯
Apostolia Lamprinou,

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯
Fausto Machicao,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯
Fritz Schick,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany, Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, University Hospital Tübingen, Tübingen, Germany
⨯
Andreas Fritsche,

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany, Department of Internal Medicine, Division of Nutritional and Preventive Medicine, University Hospital Tübingen, Tübingen, Germany
⨯
Norbert Stefan,

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯
Bernd Nürnberg,

Affiliation Department of Experimental and Clinical Pharmacology and Toxicology, Division of Pharmacology and Experimental Therapy, University Hospital Tübingen, Tübingen, Germany
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Hans-Ulrich Häring,

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯
Harald Staiger

* E-mail: harald.staiger@med.uni-tuebingen.de

Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Tübingen, Germany
⨯

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers

Martin Kächele,
Anita M. Hennige,
Jürgen Machann,
Anja Hieronimus,
Apostolia Lamprinou,
Fausto Machicao,
Fritz Schick,
Andreas Fritsche,
Norbert Stefan,
Bernd Nürnberg

Published: December 10, 2015
https://doi.org/10.1371/journal.pone.0144494

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