Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

Naïg Gueguen; Valérie Desquiret-Dumas; Géraldine Leman; Stéphanie Chupin; Stéphanie Baron; Valérie Nivet-Antoine; Emilie Vessières; Audrey Ayer; Daniel Henrion; Guy Lenaers; Pascal Reynier; Vincent Procaccio

doi:10.1371/journal.pone.0144290

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Peer-reviewed

Research Article

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

Naïg Gueguen ,

Contributed equally to this work with: Naïg Gueguen, Valérie Desquiret-Dumas, Géraldine Leman

* E-mail: NaGueguen@chu-angers.fr

Affiliations Université d’Angers, Angers, F-49000, France, Département de Biochimie et Génétique, CHU d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Valérie Desquiret-Dumas ,

Contributed equally to this work with: Naïg Gueguen, Valérie Desquiret-Dumas, Géraldine Leman

Affiliations Université d’Angers, Angers, F-49000, France, Département de Biochimie et Génétique, CHU d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Géraldine Leman ,

Contributed equally to this work with: Naïg Gueguen, Valérie Desquiret-Dumas, Géraldine Leman

Affiliations Université d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Stéphanie Chupin,

Affiliations Université d’Angers, Angers, F-49000, France, Département de Biochimie et Génétique, CHU d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Stéphanie Baron,

Affiliation EA 4466, Université Paris Descartes, Faculté de Pharmacie, Paris, F-75270, France
⨯
Valérie Nivet-Antoine,

Affiliation EA 4466, Université Paris Descartes, Faculté de Pharmacie, Paris, F-75270, France
⨯
Emilie Vessières,

Affiliations Université d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Audrey Ayer,

Affiliations Université d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Daniel Henrion,

Affiliations Université d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Guy Lenaers,

Affiliations Université d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Pascal Reynier,

Affiliations Université d’Angers, Angers, F-49000, France, Département de Biochimie et Génétique, CHU d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯
Vincent Procaccio

Affiliations Université d’Angers, Angers, F-49000, France, Département de Biochimie et Génétique, CHU d’Angers, Angers, F-49000, France, UMR CNRS 6214-INSERM U1083, Angers, F-49000, France
⨯

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

Naïg Gueguen,
Valérie Desquiret-Dumas,
Géraldine Leman,
Stéphanie Chupin,
Stéphanie Baron,
Valérie Nivet-Antoine,
Emilie Vessières,
Audrey Ayer,
Daniel Henrion,
Guy Lenaers

Published: December 18, 2015
https://doi.org/10.1371/journal.pone.0144290

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