Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

Ana Martínez-Zamora; Salvador Meseguer; Juan M. Esteve; Magda Villarroya; Carmen Aguado; J. Antonio Enríquez; Erwin Knecht; M.-Eugenia Armengod

doi:10.1371/journal.pone.0144273

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Research Article

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

Ana Martínez-Zamora ,

Contributed equally to this work with: Ana Martínez-Zamora, Salvador Meseguer

Affiliation Laboratory of RNA Modification and Mitochondrial Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain
⨯
Salvador Meseguer ,

Contributed equally to this work with: Ana Martínez-Zamora, Salvador Meseguer

Affiliation Laboratory of RNA Modification and Mitochondrial Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain
⨯
Juan M. Esteve,

Current address: Departamento de Medicina y Cirugía, CEU Universidad Cardenal Herrera, Castellón, Spain

Affiliation Laboratory of Intracellular Protein Degradation and Rare Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain
⨯
Magda Villarroya,

Affiliation Laboratory of RNA Modification and Mitochondrial Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain
⨯
Carmen Aguado,

Affiliations Laboratory of Intracellular Protein Degradation and Rare Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain, Centro de Investigación Biomédica En Red de Enfermedades Raras (CIBERER), node U721, Valencia, Spain
⨯
J. Antonio Enríquez,

Affiliations Departamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
⨯
Erwin Knecht,

Affiliations Laboratory of Intracellular Protein Degradation and Rare Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain, Centro de Investigación Biomédica En Red de Enfermedades Raras (CIBERER), node U721, Valencia, Spain
⨯
M.-Eugenia Armengod

* E-mail: marmengod@cipf.es

Affiliations Laboratory of RNA Modification and Mitochondrial Diseases, Centro de Investigación Príncipe Felipe, Valencia, Spain, Centro de Investigación Biomédica En Red de Enfermedades Raras (CIBERER), node U721, Valencia, Spain
⨯

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

Ana Martínez-Zamora,
Salvador Meseguer,
Juan M. Esteve,
Magda Villarroya,
Carmen Aguado,
J. Antonio Enríquez,
Erwin Knecht,
M.-Eugenia Armengod

Published: December 7, 2015
https://doi.org/10.1371/journal.pone.0144273

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