Fluorescence Adherence Inhibition Assay: A Novel Functional Assessment of Blocking Virus Attachment by Vaccine-Induced Antibodies

Atul Asati; Olga Kachurina; Alex Karol; Vipra Dhir; Michael Nguyen; Robert Parkhill; Diana Kouiavskaia; Konstantin Chumakov; William Warren; Anatoly Kachurin

doi:10.1371/journal.pone.0144261

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Open Access

Peer-reviewed

Research Article

Fluorescence Adherence Inhibition Assay: A Novel Functional Assessment of Blocking Virus Attachment by Vaccine-Induced Antibodies

Atul Asati,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Olga Kachurina,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Alex Karol,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Vipra Dhir,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Michael Nguyen,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Robert Parkhill,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Diana Kouiavskaia,

Affiliation U. S. Food and Drug Administration, Center for Biologics Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States of America
⨯
Konstantin Chumakov,

Affiliation U. S. Food and Drug Administration, Center for Biologics Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States of America
⨯
William Warren,

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯
Anatoly Kachurin

* E-mail: anatoly.kachurin@sanofipasteur.com

Affiliation Sanofi Pasteur VaxDesign Campus, 2501 Discovery Dr. Suite 3000, Orlando, Florida 32826, United States of America
⨯

Fluorescence Adherence Inhibition Assay: A Novel Functional Assessment of Blocking Virus Attachment by Vaccine-Induced Antibodies

Atul Asati,
Olga Kachurina,
Alex Karol,
Vipra Dhir,
Michael Nguyen,
Robert Parkhill,
Diana Kouiavskaia,
Konstantin Chumakov,
William Warren,
Anatoly Kachurin

Published: February 10, 2016
https://doi.org/10.1371/journal.pone.0144261

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