Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

Eun Mi Chang; Eunjin Lim; Sookyoung Yoon; Kyungah Jeong; Sijeong Bae; Dong Ryul Lee; Tae Ki Yoon; Youngsok Choi; Woo Sik Lee

doi:10.1371/journal.pone.0144245

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Research Article

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

Eun Mi Chang,

Affiliation Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea
⨯
Eunjin Lim,

Affiliation Department of Biomedical Science, CHA University, Sungnam-Si, Republic of Korea
⨯
Sookyoung Yoon,

Affiliations Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea, Department of Biomedical Science, CHA University, Sungnam-Si, Republic of Korea
⨯
Kyungah Jeong,

Affiliation Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
⨯
Sijeong Bae,

Affiliation Department of Biomedical Science, CHA University, Sungnam-Si, Republic of Korea
⨯
Dong Ryul Lee,

Affiliations Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea, Department of Biomedical Science, CHA University, Sungnam-Si, Republic of Korea
⨯
Tae Ki Yoon,

Affiliation Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea
⨯
Youngsok Choi ,

Contributed equally to this work with: Youngsok Choi, Woo Sik Lee

* E-mail: youngsokchoi@cha.ac.kr (YC); wooslee@cha.ac.kr (WL)

Affiliation Department of Biomedical Science, CHA University, Sungnam-Si, Republic of Korea
⨯
Woo Sik Lee

Contributed equally to this work with: Youngsok Choi, Woo Sik Lee

* E-mail: youngsokchoi@cha.ac.kr (YC); wooslee@cha.ac.kr (WL)

Affiliation Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea
⨯

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

Eun Mi Chang,
Eunjin Lim,
Sookyoung Yoon,
Kyungah Jeong,
Sijeong Bae,
Dong Ryul Lee,
Tae Ki Yoon,
Youngsok Choi,
Woo Sik Lee

Published: December 14, 2015
https://doi.org/10.1371/journal.pone.0144245

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