Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples

Ensel Oh; Yoon-La Choi; Mi Jeong Kwon; Ryong Nam Kim; Yu Jin Kim; Ji-Young Song; Kyung Soo Jung; Young Kee Shin

doi:10.1371/journal.pone.0144162

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Open Access

Peer-reviewed

Research Article

Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples

Ensel Oh ,

Contributed equally to this work with: Ensel Oh, Yoon-La Choi

Affiliations Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, Korea, Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea
⨯
Yoon-La Choi ,

Contributed equally to this work with: Ensel Oh, Yoon-La Choi

Affiliations Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, Korea, Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Mi Jeong Kwon,

Affiliations College of Pharmacy, Kyungpook National University, Daegu, Korea, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu, Korea
⨯
Ryong Nam Kim,

Affiliation Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea
⨯
Yu Jin Kim,

Affiliations Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, Korea
⨯
Ji-Young Song,

Affiliations Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, Korea
⨯
Kyung Soo Jung,

Affiliations Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Young Kee Shin

* E-mail: ykeeshin@snu.ac.kr

Affiliation Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea
⨯

Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples

Ensel Oh,
Yoon-La Choi,
Mi Jeong Kwon,
Ryong Nam Kim,
Yu Jin Kim,
Ji-Young Song,
Kyung Soo Jung,
Young Kee Shin

Published: December 7, 2015
https://doi.org/10.1371/journal.pone.0144162

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DNA sequencing
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DNA damage
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Somatic mutation
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Homozygosity
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Formalin fixation
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Nucleotide sequencing
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Cancers and neoplasms
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