Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice

Lin Lu; Lan Guo; Esha Gauba; Jing Tian; Lu Wang; Neha Tandon; Malini Shankar; Simon J. Beck; Yifeng Du; Heng Du

doi:10.1371/journal.pone.0144068

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Open Access

Peer-reviewed

Research Article

Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice

Lin Lu,

Affiliations Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, The People’s Republic of China
⨯
Lan Guo,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Esha Gauba,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Jing Tian,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Lu Wang,

Affiliations Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, The People’s Republic of China
⨯
Neha Tandon,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Malini Shankar,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Simon J. Beck,

Affiliation Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Yifeng Du ,

* E-mail: heng.du@utdallas.edu (HD); duyifeng2013@163.com (YD)

Affiliation Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, The People’s Republic of China
⨯
Heng Du

* E-mail: heng.du@utdallas.edu (HD); duyifeng2013@163.com (YD)

Affiliations Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, United States of America, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, The People’s Republic of China
⨯

Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice

Lin Lu,
Lan Guo,
Esha Gauba,
Jing Tian,
Lu Wang,
Neha Tandon,
Malini Shankar,
Simon J. Beck,
Yifeng Du,
Heng Du

Published: December 3, 2015
https://doi.org/10.1371/journal.pone.0144068

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Mitochondria
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Cerebral ischemia
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Alzheimer's disease
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Transient ischemic attacks
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