Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species^†

• Hengjie Yuan,

  Affiliations Bloodworks Northwest Research Institute, Seattle, Washington, United States of America, Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin, China

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• Katie L. Houck,

  Affiliation Bloodworks Northwest Research Institute, Seattle, Washington, United States of America

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• Ye Tian,

  Affiliations Bloodworks Northwest Research Institute, Seattle, Washington, United States of America, Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin, China

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• Uddalak Bharadwaj,

  Affiliation Division of Infectious Disease, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Ken Hull,

  Affiliation The Natural Products LINCHPIN Laboratory and Department of Chemistry, Texas A & M University, College Station, Texas, United States of America

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• Zhou Zhou,

  Affiliation Bloodworks Northwest Research Institute, Seattle, Washington, United States of America

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• Mingzhao Zhou,

  Affiliation The Natural Products LINCHPIN Laboratory and Department of Chemistry, Texas A & M University, College Station, Texas, United States of America

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• Xiaoping Wu,

  Affiliation Bloodworks Northwest Research Institute, Seattle, Washington, United States of America

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• David J. Tweardy,

  Affiliation Division of Infectious Disease, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Daniel Romo,

  Affiliation The Natural Products LINCHPIN Laboratory and Department of Chemistry, Texas A & M University, College Station, Texas, United States of America

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• Xiaoyun Fu,

  Affiliations Bloodworks Northwest Research Institute, Seattle, Washington, United States of America, Division of Hematology, Department of Medicine, University of Washington, School of Medicine, Seattle, Washington, United States of America

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• Yanjun Zhang,

  Affiliation Medicine Division, Imperial College London, London, United Kingdom

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• Jianning Zhang ,

  * E-mail: jfdong@BloodworksNW.org (JFD); jianningzhang@hotmail.com (JZ)

  Affiliation Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin, China

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• Jing-fei Dong

  * E-mail: jfdong@BloodworksNW.org (JFD); jianningzhang@hotmail.com (JZ)

  Affiliations Bloodworks Northwest Research Institute, Seattle, Washington, United States of America, Division of Hematology, Department of Medicine, University of Washington, School of Medicine, Seattle, Washington, United States of America

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