Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Elena Montes-Cobos; Xiao Li; Henrike J. Fischer; André Sasse; Sebastian Kügler; Michael Didié; Karl Toischer; Martin Fassnacht; Ralf Dressel; Holger M. Reichardt

doi:10.1371/journal.pone.0143954

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Research Article

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Elena Montes-Cobos,

Affiliation Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯
Xiao Li,

Affiliation Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯
Henrike J. Fischer,

Affiliation Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯
André Sasse,

Affiliation Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯
Sebastian Kügler,

Affiliation Department of Neurology, Center for Molecular Physiology of the Brain, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯
Michael Didié,

Affiliations Institute of Pharmacology, University Medical Center Göttingen, 37073 Göttingen, Germany, Department of Cardiology and Pneumology, University Medical Center Göttingen, 37073 Göttingen, Germany, Partner site Göttingen, German Center for Cardiovascular Research (DZHK), 37073 Göttingen, Germany
⨯
Karl Toischer,

Affiliations Department of Cardiology and Pneumology, University Medical Center Göttingen, 37073 Göttingen, Germany, Partner site Göttingen, German Center for Cardiovascular Research (DZHK), 37073 Göttingen, Germany
⨯
Martin Fassnacht,

Affiliation Endocrine and Diabetes Unit, Department of Internal Medicine I, University of Würzburg, 97080 Würzburg, Germany
⨯
Ralf Dressel,

Affiliations Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany, Partner site Göttingen, German Center for Cardiovascular Research (DZHK), 37073 Göttingen, Germany
⨯
Holger M. Reichardt

* E-mail: hreichardt@med.uni-goettingen.de

Affiliation Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany
⨯

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Elena Montes-Cobos,
Xiao Li,
Henrike J. Fischer,
André Sasse,
Sebastian Kügler,
Michael Didié,
Karl Toischer,
Martin Fassnacht,
Ralf Dressel,
Holger M. Reichardt

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0143954

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