Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

Open Access

Peer-reviewed

Research Article

Kelly Hew,

Affiliation Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
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Sue-Li Dahlroth,

Affiliation Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
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Saranya Veerappan,

Affiliation Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
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Lucy Xin Pan,

Affiliation Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
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Tobias Cornvik,

Affiliation Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
⨯
Pär Nordlund

* E-mail: pnordlund@ntu.edu.sg

Affiliations Division of Structural Biology and Biochemistry, Nanyang Technological University, School of Biological Sciences, Singapore, Singapore, Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore
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Crystal structure
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Phosphorylation
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Melting
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Pyrimidines
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Monomers
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Nucleosides
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Phosphates
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Electron density
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