Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

Victoria Arena de Souza; David J. Scott; Joanne E. Nettleship; Nahid Rahman; Michael H. Charlton; Martin A. Walsh; Raymond J. Owens

doi:10.1371/journal.pone.0143919

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Peer-reviewed

Research Article

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

Victoria Arena de Souza,

Affiliations UK OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, United Kingdom, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom
⨯
David J. Scott,

Affiliations The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire, United Kingdom
⨯
Joanne E. Nettleship,

Affiliations UK OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
⨯
Nahid Rahman,

Affiliations UK OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
⨯
Michael H. Charlton,

Current address: InhibOx, Ltd, Oxford Centre for Innovation, New Road, Oxford, OX11BY, United Kingdom

Affiliation Chroma Therapeutics Ltd., 93 Innovation Drive Milton Park, Abingdon, United Kingdom
⨯
Martin A. Walsh ,

* E-mail: martin.walsh@diamond.ac.uk (MAW); ray@strubi.ox.ac.uk (RJO)

Affiliations The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom
⨯
Raymond J. Owens

* E-mail: martin.walsh@diamond.ac.uk (MAW); ray@strubi.ox.ac.uk (RJO)

Affiliations UK OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory Harwell Oxford, Oxfordshire, United Kingdom, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
⨯

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

Victoria Arena de Souza,
David J. Scott,
Joanne E. Nettleship,
Nahid Rahman,
Michael H. Charlton,
Martin A. Walsh,
Raymond J. Owens

Published: December 11, 2015
https://doi.org/10.1371/journal.pone.0143919

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