Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Jacqueline Stockley; Shaista P. Nisar; Vincenzo C. Leo; Essa Sabi; Margaret R. Cunningham; Jeroen C. Eikenboom; Stefan Lethagen; Reinhard Schneppenheim; Anne C. Goodeve; Steve P. Watson; Stuart J. Mundell; Martina E. Daly; GAPP study in collaboration with the MCMDM-1VWD study group

doi:10.1371/journal.pone.0143913

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Open Access

Peer-reviewed

Research Article

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Jacqueline Stockley ,

Contributed equally to this work with: Jacqueline Stockley, Shaista P. Nisar

Affiliation Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
⨯
Shaista P. Nisar ,

Contributed equally to this work with: Jacqueline Stockley, Shaista P. Nisar

Affiliation School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
⨯
Vincenzo C. Leo,

Affiliation Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
⨯
Essa Sabi,

Affiliation Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
⨯
Margaret R. Cunningham,

Affiliation School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
⨯
Jeroen C. Eikenboom,

Affiliation Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
⨯
Stefan Lethagen,

Affiliation National Haemophilia Center, University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯
Reinhard Schneppenheim,

Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Anne C. Goodeve,

Affiliation Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
⨯
Steve P. Watson,

Affiliation Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Stuart J. Mundell,

Affiliation School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
⨯
Martina E. Daly ,

* E-mail: m.daly@sheffield.ac.uk

Affiliation Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
⨯
GAPP study in collaboration with the MCMDM-1VWD study group

¶Membership of the MCMDM-1VWD study group is provided in the Acknowledgments.
⨯

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Jacqueline Stockley,
Shaista P. Nisar,
Vincenzo C. Leo,
Essa Sabi,
Margaret R. Cunningham,
Jeroen C. Eikenboom,
Stefan Lethagen,
Reinhard Schneppenheim,
Anne C. Goodeve,
Steve P. Watson

Published: December 2, 2015
https://doi.org/10.1371/journal.pone.0143913

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