The Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish

Angeliki Lyssimachou; Joana G. Santos; Ana André; Joana Soares; Daniela Lima; Laura Guimarães; C. Marisa R. Almeida; Catarina Teixeira; L. Filipe C. Castro; Miguel M. Santos

doi:10.1371/journal.pone.0143911

Loading metrics

Open Access

Peer-reviewed

Research Article

The Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish

Angeliki Lyssimachou ,

* E-mail: angeliki@ciimar.up.pt (AL); filipe.castro@ciimar.up.pt (LFCC); santos@ciimar.up.pt (MMS)

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Joana G. Santos,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Ana André,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Joana Soares,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Daniela Lima,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Laura Guimarães,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
C. Marisa R. Almeida,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Catarina Teixeira,

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
L. Filipe C. Castro ,

* E-mail: angeliki@ciimar.up.pt (AL); filipe.castro@ciimar.up.pt (LFCC); santos@ciimar.up.pt (MMS)

Affiliation CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal
⨯
Miguel M. Santos

* E-mail: angeliki@ciimar.up.pt (AL); filipe.castro@ciimar.up.pt (LFCC); santos@ciimar.up.pt (MMS)

Affiliations CIMAR/CIIMAR-AL, Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, 4050–123, Porto, Portugal, FCUP–Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal
⨯

The Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish

Angeliki Lyssimachou,
Joana G. Santos,
Ana André,
Joana Soares,
Daniela Lima,
Laura Guimarães,
C. Marisa R. Almeida,
Catarina Teixeira,
L. Filipe C. Castro,
Miguel M. Santos

Published: December 3, 2015
https://doi.org/10.1371/journal.pone.0143911

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Zebrafish
Is the Subject Area "Zebrafish" applicable to this article?

Thanks for your feedback.
Lipid metabolism
Is the Subject Area "Lipid metabolism" applicable to this article?

Thanks for your feedback.
Fatty liver
Is the Subject Area "Fatty liver" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Enzyme regulation
Is the Subject Area "Enzyme regulation" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
Enzyme metabolism
Is the Subject Area "Enzyme metabolism" applicable to this article?

Thanks for your feedback.