Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

Serena Guidotti; Manuela Minguzzi; Daniela Platano; Luca Cattini; Giovanni Trisolino; Erminia Mariani; Rosa Maria Borzì

doi:10.1371/journal.pone.0143865

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Research Article

Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

Serena Guidotti ,

Contributed equally to this work with: Serena Guidotti, Manuela Minguzzi

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento di Scienze Mediche e Chirurgiche-DIMEC, Università di Bologna, Bologna, Italy
⨯
Manuela Minguzzi ,

Contributed equally to this work with: Serena Guidotti, Manuela Minguzzi

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento di Scienze Mediche e Chirurgiche-DIMEC, Università di Bologna, Bologna, Italy
⨯
Daniela Platano,

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento di Scienze Mediche e Chirurgiche-DIMEC, Università di Bologna, Bologna, Italy, Dipartimento di Scienze Biomediche e Neuromotorie-DIBINEM, Università di Bologna, Bologna, Italy
⨯
Luca Cattini,

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento RIT, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯
Giovanni Trisolino,

Affiliation Chirurgia ricostruttiva articolare dell’anca e del ginocchio, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯
Erminia Mariani,

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento di Scienze Mediche e Chirurgiche-DIMEC, Università di Bologna, Bologna, Italy, Dipartimento RIT, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯
Rosa Maria Borzì

* E-mail: rosamaria.borzi@ior.it

Affiliations Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento RIT, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯

Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

Serena Guidotti,
Manuela Minguzzi,
Daniela Platano,
Luca Cattini,
Giovanni Trisolino,
Erminia Mariani,
Rosa Maria Borzì

Published: November 30, 2015
https://doi.org/10.1371/journal.pone.0143865

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Chondrocytes
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Cartilage
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Osteoarthritis
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Cell staining
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Senescence
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