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Open Access
Peer-reviewed
Research Article
Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity
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Seulah Choi ,
Contributed equally to this work with: Seulah Choi, Donghoon Kim
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana, United States of America
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Donghoon Kim ,
Contributed equally to this work with: Seulah Choi, Donghoon Kim
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana, United States of America
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Tae-In Kam,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Seungpil Yun,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana, United States of America
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Sangjune Kim,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Hyejin Park,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Heehong Hwang,
Affiliation Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Olga Pletnikova,
Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Juan C. Troncoso,
Affiliations Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Valina L. Dawson,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana, United States of America
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Ted M. Dawson,
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana, United States of America
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Han Seok Ko
* E-mail: hko3@jhmi.edu
Affiliations Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana, United States of America
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Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity
- Seulah Choi,
- Donghoon Kim,
- Tae-In Kam,
- Seungpil Yun,
- Sangjune Kim,
- Hyejin Park,
- Heehong Hwang,
- Olga Pletnikova,
- Juan C. Troncoso,
- Valina L. Dawson
- Published: December 2, 2015
- https://doi.org/10.1371/journal.pone.0143854