Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai; Yu-Chih Wang; Tony Tung-Yin Lee; Cheng-Fang Tsai; Hung-Sheng Chen; Feng-Jie Lai; Kazunari K. Yokoyama; Tsung-Hsun Hsieh; Ruey-Meei Wu; Jau-nan Lee

doi:10.1371/journal.pone.0143852

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Open Access

Peer-reviewed

Research Article

Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai ,

Contributed equally to this work with: Eing-Mei Tsai, Yu-Chih Wang

Affiliation Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital and Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯
Yu-Chih Wang ,

Contributed equally to this work with: Eing-Mei Tsai, Yu-Chih Wang

Affiliation Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital and Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯
Tony Tung-Yin Lee,

Affiliation Accelerated Biosciences Corp., Manhattan Beach, California 90266, United States of America
⨯
Cheng-Fang Tsai,

Affiliation Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯
Hung-Sheng Chen,

Affiliations Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital and Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯
Feng-Jie Lai,

Affiliation Department of Dermatology, Chi-Mei Medical Center, Tainan 710, Taiwan
⨯
Kazunari K. Yokoyama,

Affiliation Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯
Tsung-Hsun Hsieh,

Affiliation Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
⨯
Ruey-Meei Wu,

Affiliation Department of Neurology, National Taiwan University Hospital, Taipei 10048, Taiwan
⨯
Jau-nan Lee

* E-mail: jaunanlee@outlook.com

Affiliation Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital and Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
⨯

Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai,
Yu-Chih Wang,
Tony Tung-Yin Lee,
Cheng-Fang Tsai,
Hung-Sheng Chen,
Feng-Jie Lai,
Kazunari K. Yokoyama,
Tsung-Hsun Hsieh,
Ruey-Meei Wu,
Jau-nan Lee

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0143852

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DNA transcription
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G-protein signaling
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Stem cells
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Neurons
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Neuronal differentiation
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Cell differentiation
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Genomic signal processing
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