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Open Access
Peer-reviewed
Research Article
Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT)
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Hendrik P. N. Scholl ,
Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
* E-mail: hscholl1@jhmi.edu
¶‡ These authors are shared first authors on this work.
Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America
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Anthony T. Moore ,
Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
¶‡ These authors are shared first authors on this work.
Affiliations Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom, Dept. of Ophthalmology, University of California San Francisco, San Francisco, CA, United States of America
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Robert K. Koenekoop ,
Contributed equally to this work with: Hendrik P. N. Scholl, Anthony T. Moore, Robert K. Koenekoop
¶‡ These authors are shared first authors on this work.
Affiliation McGill University Health Centre, Montreal, Quebec, Canada
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Yuquan Wen,
Affiliations Retina Foundation of the Southwest, Dallas, TX, United States of America, Baylor Visual Function Center, Baylor University Medical Center, Dallas, TX, United States of America
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Gerald A. Fishman,
Affiliation Chicago Lighthouse, Pangere Center for Inherited Retinal Diseases, Chicago, IL, United States of America
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L. Ingeborgh van den Born,
Affiliation Rotterdam Eye Hospital and Ophthalmic Institute, Rotterdam, The Netherlands
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Ava Bittner,
Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, Nova Southeastern University, College of Optometry, Fort Lauderdale, FL, United States of America
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Kristen Bowles,
Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, College of Optometry, University of Houston, Houston, TX, United States of America
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Emily C. Fletcher,
Affiliations Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America, Gloucester Royal NHS Foundation Trust, Gloucester Royal Hospitals, Gloucester, United Kingdom
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Frederick T. Collison,
Affiliation Chicago Lighthouse, Pangere Center for Inherited Retinal Diseases, Chicago, IL, United States of America
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Gislin Dagnelie,
Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America
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Simona Degli Eposti,
Affiliation Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom
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Michel Michaelides,
Affiliation Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, United Kingdom
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David A. Saperstein,
Affiliations Vitreoretinal Associates of Washington, Seattle, WA, United States of America, QLT Inc., Vancouver, Canada
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Ronald A. Schuchard,
Affiliations QLT Inc., Vancouver, Canada, Stanford Univ School of Medicine, Palo Alto, CA, United States of America
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Claire Barnes,
Affiliations QLT Inc., Vancouver, Canada, VA Palo Alto Health Care System, Palo Alto, CA, United States of America
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Wadih Zein,
Affiliation Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, United States of America
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Ditta Zobor,
Affiliation Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany
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David G. Birch,
Affiliations Retina Foundation of the Southwest, Dallas, TX, United States of America, Ophthalmology, UT Southwestern, Dallas, TX, United States of America
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Janine D. Mendola,
Affiliation McGill University Health Centre, Montreal, Quebec, Canada
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Eberhart Zrenner,
Affiliation Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany
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RET IRD 01 Study Group
¶Membership of the RET IRD 01 Study Group is listed in the Acknowledgments.
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Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT)
- Hendrik P. N. Scholl,
- Anthony T. Moore,
- Robert K. Koenekoop,
- Yuquan Wen,
- Gerald A. Fishman,
- L. Ingeborgh van den Born,
- Ava Bittner,
- Kristen Bowles,
- Emily C. Fletcher,
- Frederick T. Collison
- Published: December 10, 2015
- https://doi.org/10.1371/journal.pone.0143846