Large Neutral Amino Acid Supplementation Exerts Its Effect through Three Synergistic Mechanisms: Proof of Principle in Phenylketonuria Mice

• Danique van Vliet,

  Affiliations University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Groningen, The Netherlands, University of Groningen, Center of Behavior and Neurosciences, Department of Molecular Neurobiology, Groningen, The Netherlands

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• Vibeke M. Bruinenberg,

  Affiliation University of Groningen, Center of Behavior and Neurosciences, Department of Molecular Neurobiology, Groningen, The Netherlands

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• Priscila N. Mazzola,

  Affiliations University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Groningen, The Netherlands, University of Groningen, Center of Behavior and Neurosciences, Department of Molecular Neurobiology, Groningen, The Netherlands

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• Martijn H. J. R. van Faassen,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands

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• Pim de Blaauw,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands

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• Ido P. Kema,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands

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• M. Rebecca Heiner-Fokkema,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands

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• Rogier D. van Anholt,

  Affiliation Independent Researcher, Deventer, The Netherlands

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• Eddy A. van der Zee,

  Affiliation University of Groningen, Center of Behavior and Neurosciences, Department of Molecular Neurobiology, Groningen, The Netherlands

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• Francjan J. van Spronsen

  * E-mail: f.j.van.spronsen@umcg.nl

  Affiliation University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Groningen, The Netherlands

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