Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Erli Zhang; Qianyun Guo; Haiyang Gao; Ruixia Xu; Siyong Teng; Yongjian Wu

doi:10.1371/journal.pone.0143814

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Peer-reviewed

Research Article

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Erli Zhang ,

Contributed equally to this work with: Erli Zhang, Qianyun Guo

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Qianyun Guo ,

Contributed equally to this work with: Erli Zhang, Qianyun Guo

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Haiyang Gao,

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Ruixia Xu,

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Siyong Teng,

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yongjian Wu

* E-mail: aricho1985@163.com

Affiliation State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital, and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Erli Zhang,
Qianyun Guo,
Haiyang Gao,
Ruixia Xu,
Siyong Teng,
Yongjian Wu

Published: December 2, 2015
https://doi.org/10.1371/journal.pone.0143814

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