Fn14, a Downstream Target of the TGF-β Signaling Pathway, Regulates Fibroblast Activation

Shaoxian Chen; Juli Liu; Min Yang; Wen Lai; Litong Ye; Jing Chen; Xinghua Hou; Hong Ding; Wenwei Zhang; Yueheng Wu; Xiaoying Liu; Shufang Huang; Xiyong Yu; Dingzhang Xiao

doi:10.1371/journal.pone.0143802

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Open Access

Peer-reviewed

Research Article

Fn14, a Downstream Target of the TGF-β Signaling Pathway, Regulates Fibroblast Activation

Shaoxian Chen ,

Contributed equally to this work with: Shaoxian Chen, Juli Liu

¶‡ These authors are co-first authors on this work.

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Juli Liu ,

Contributed equally to this work with: Shaoxian Chen, Juli Liu

¶‡ These authors are co-first authors on this work.

Affiliation Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China
⨯
Min Yang,

Affiliations Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China, Pharmacy Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Wen Lai,

Affiliation Burn and Wound Repair Surgery of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Litong Ye,

Affiliation Pharmacy Department of General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong, China
⨯
Jing Chen,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Xinghua Hou,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Hong Ding,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Wenwei Zhang,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Yueheng Wu,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Xiaoying Liu,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Shufang Huang,

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Xiyong Yu ,

* E-mail: dzhxiao@163.com (DX); yuxycn@aliyun.com (XY)

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Dingzhang Xiao

* E-mail: dzhxiao@163.com (DX); yuxycn@aliyun.com (XY)

Affiliation Medical Research Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯

Fn14, a Downstream Target of the TGF-β Signaling Pathway, Regulates Fibroblast Activation

Shaoxian Chen,
Juli Liu,
Min Yang,
Wen Lai,
Litong Ye,
Jing Chen,
Xinghua Hou,
Hong Ding,
Wenwei Zhang,
Yueheng Wu

Published: December 1, 2015
https://doi.org/10.1371/journal.pone.0143802

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Fibroblasts
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Small interfering RNA
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Protein expression
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Fibrosis
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TGF-beta signaling cascade
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SMAD signaling
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