Fentanyl Enhances Hepatotoxicity of Paclitaxel via Inhibition of CYP3A4 and ABCB1 Transport Activity in Mice

Jing-Dun Xie; Yang Huang; Dong-Tai Chen; Jia-Hao Pan; Bing-Tian Bi; Kun-Yao Feng; Wan Huang; Wei-An Zeng

doi:10.1371/journal.pone.0143701

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Open Access

Peer-reviewed

Research Article

Fentanyl Enhances Hepatotoxicity of Paclitaxel via Inhibition of CYP3A4 and ABCB1 Transport Activity in Mice

Jing-Dun Xie ,

Contributed equally to this work with: Jing-Dun Xie, Yang Huang, Dong-Tai Chen

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Yang Huang ,

Contributed equally to this work with: Jing-Dun Xie, Yang Huang, Dong-Tai Chen

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Dong-Tai Chen ,

Contributed equally to this work with: Jing-Dun Xie, Yang Huang, Dong-Tai Chen

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Jia-Hao Pan,

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Bing-Tian Bi,

Affiliation Department of Clinical Trial Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Kun-Yao Feng,

Affiliation Department of Clinical Trial Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Wan Huang,

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯
Wei-An Zeng

* E-mail: zengwa@mail.sysu.edu.cn

Affiliation Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China
⨯

Fentanyl Enhances Hepatotoxicity of Paclitaxel via Inhibition of CYP3A4 and ABCB1 Transport Activity in Mice

Jing-Dun Xie,
Yang Huang,
Dong-Tai Chen,
Jia-Hao Pan,
Bing-Tian Bi,
Kun-Yao Feng,
Wan Huang,
Wei-An Zeng

Published: December 3, 2015
https://doi.org/10.1371/journal.pone.0143701

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