Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

Christina Dammers; Lothar Gremer; Kerstin Reiß; Antonia N. Klein; Philipp Neudecker; Rudolf Hartmann; Na Sun; Hans-Ulrich Demuth; Melanie Schwarten; Dieter Willbold

doi:10.1371/journal.pone.0143647

Loading metrics

Open Access

Peer-reviewed

Research Article

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

Christina Dammers,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Lothar Gremer,

Affiliations Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany, Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
⨯
Kerstin Reiß,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Antonia N. Klein,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Philipp Neudecker,

Affiliations Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany, Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
⨯
Rudolf Hartmann,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Na Sun,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Hans-Ulrich Demuth,

Affiliation Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, 06120, Halle (Saale), Germany
⨯
Melanie Schwarten,

Affiliation Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany
⨯
Dieter Willbold

* E-mail: d.willbold@fz-juelich.de

Affiliations Institute of Complex Systems (ICS-6) Structural Biochemistry, Forschungszentrum Jülich, 52425, Jülich, Germany, Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany
⨯

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

Christina Dammers,
Lothar Gremer,
Kerstin Reiß,
Antonia N. Klein,
Philipp Neudecker,
Rudolf Hartmann,
Na Sun,
Hans-Ulrich Demuth,
Melanie Schwarten,
Dieter Willbold

Published: November 23, 2015
https://doi.org/10.1371/journal.pone.0143647

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phosphates
Is the Subject Area "Phosphates" applicable to this article?

Thanks for your feedback.
Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Aqueous solutions
Is the Subject Area "Aqueous solutions" applicable to this article?

Thanks for your feedback.
NMR spectroscopy
Is the Subject Area "NMR spectroscopy" applicable to this article?

Thanks for your feedback.
Circular dichroism spectroscopy
Is the Subject Area "Circular dichroism spectroscopy" applicable to this article?

Thanks for your feedback.
Monomers
Is the Subject Area "Monomers" applicable to this article?

Thanks for your feedback.
Transmission electron microscopy
Is the Subject Area "Transmission electron microscopy" applicable to this article?

Thanks for your feedback.
Two-dimensional NMR spectroscopy
Is the Subject Area "Two-dimensional NMR spectroscopy" applicable to this article?

Thanks for your feedback.