Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

Anna Massó; Angela Sánchez; Lydia Gimenez-Llort; Jose Miguel Lizcano; Manuel Cañete; Belen García; Virginia Torres-Lista; Meritxell Puig; Assumpció Bosch; Miguel Chillon

doi:10.1371/journal.pone.0143623

Loading metrics

Open Access

Peer-reviewed

Research Article

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

Anna Massó,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Angela Sánchez,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Lydia Gimenez-Llort,

Affiliations Institut de Neurociencies, Universitat Autònoma Barcelona, Bellaterra, Spain, Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Jose Miguel Lizcano,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Institut de Neurociencies, Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Manuel Cañete,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Belen García,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Virginia Torres-Lista,

Affiliations Institut de Neurociencies, Universitat Autònoma Barcelona, Bellaterra, Spain, Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Meritxell Puig,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Assumpció Bosch,

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain
⨯
Miguel Chillon

* E-mail: miguel.chillon@uab.es

Affiliations Departament Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma Barcelona, Bellaterra, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
⨯

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

Anna Massó,
Angela Sánchez,
Lydia Gimenez-Llort,
Jose Miguel Lizcano,
Manuel Cañete,
Belen García,
Virginia Torres-Lista,
Meritxell Puig,
Assumpció Bosch,
Miguel Chillon

Published: November 24, 2015
https://doi.org/10.1371/journal.pone.0143623

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Aging
Is the Subject Area "Aging" applicable to this article?

Thanks for your feedback.
Cerebellum
Is the Subject Area "Cerebellum" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Prefrontal cortex
Is the Subject Area "Prefrontal cortex" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.