Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion

Douglas C. Chang; Paolo Piaggi; Robert L. Hanson; William C. Knowler; John Bucci; Guene Thio; Maximilian G. Hohenadel; Clifton Bogardus; Jonathan Krakoff

doi:10.1371/journal.pone.0143551

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Open Access

Peer-reviewed

Research Article

Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion

Douglas C. Chang ,

* E-mail: changdc@mail.nih.gov

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
Paolo Piaggi,

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
Robert L. Hanson,

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
William C. Knowler,

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
John Bucci,

Affiliation Life Technologies, Carlsbad, California, United States of America
⨯
Guene Thio,

Affiliation Life Technologies, Carlsbad, California, United States of America
⨯
Maximilian G. Hohenadel,

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
Clifton Bogardus,

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯
Jonathan Krakoff

Affiliation Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, United States of America
⨯

Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion

Douglas C. Chang,
Paolo Piaggi,
Robert L. Hanson,
William C. Knowler,
John Bucci,
Guene Thio,
Maximilian G. Hohenadel,
Clifton Bogardus,
Jonathan Krakoff

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0143551

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Type 2 diabetes
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Autoantibodies
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Haplotypes
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Diabetes mellitus
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PPAR signaling
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Insulin
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Insulin secretion
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