Human GAPDH Is a Target of Aspirin’s Primary Metabolite Salicylic Acid and Its Derivatives

Hyong Woo Choi; Miaoying Tian; Murli Manohar; Maged M. Harraz; Sang-Wook Park; Frank C. Schroeder; Solomon H. Snyder; Daniel F. Klessig

doi:10.1371/journal.pone.0143447

Loading metrics

Open Access

Peer-reviewed

Research Article

Human GAPDH Is a Target of Aspirin’s Primary Metabolite Salicylic Acid and Its Derivatives

Hyong Woo Choi ,

Contributed equally to this work with: Hyong Woo Choi, Miaoying Tian

Affiliation Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America
⨯
Miaoying Tian ,

Contributed equally to this work with: Hyong Woo Choi, Miaoying Tian

Current address: Department of Plant and Environmental Protection Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, United States of America

Affiliation Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America
⨯
Murli Manohar,

Affiliation Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America
⨯
Maged M. Harraz,

Affiliation The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States of America
⨯
Sang-Wook Park,

Current address: Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, United States of America

Affiliation Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America
⨯
Frank C. Schroeder,

Affiliation Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America
⨯
Solomon H. Snyder,

Affiliation The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States of America
⨯
Daniel F. Klessig

* E-mail: dfk8@cornell.edu

Affiliations Boyce Thompson Institute for Plant Research, Cornell University, 533 Tower Road, Ithaca, New York, 14853, United States of America, Department of Plant Pathology and Plant-Microbe Biology, Cornell University, Ithaca, New York, 14853, United States of America
⨯

Human GAPDH Is a Target of Aspirin’s Primary Metabolite Salicylic Acid and Its Derivatives

Hyong Woo Choi,
Miaoying Tian,
Murli Manohar,
Maged M. Harraz,
Sang-Wook Park,
Frank C. Schroeder,
Solomon H. Snyder,
Daniel F. Klessig

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0143447

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Salicylates
Is the Subject Area "Salicylates" applicable to this article?

Thanks for your feedback.
Neuronal death
Is the Subject Area "Neuronal death" applicable to this article?

Thanks for your feedback.
Salicylic acid
Is the Subject Area "Salicylic acid" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
NMR spectroscopy
Is the Subject Area "NMR spectroscopy" applicable to this article?

Thanks for your feedback.
HEK 293 cells
Is the Subject Area "HEK 293 cells" applicable to this article?

Thanks for your feedback.
Photoaffinity labeling
Is the Subject Area "Photoaffinity labeling" applicable to this article?

Thanks for your feedback.