Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance

Emily Xie; Abhiroop Kotha; Tracy Biaco; Nikita Sedani; Jonathan Zou; Phillip Stashenko; Margaret J. Duncan; Antonio Campos-Neto; Mark J. Cayabyab

doi:10.1371/journal.pone.0143422

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Peer-reviewed

Research Article

Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance

Emily Xie,

Affiliation Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
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Abhiroop Kotha,

Affiliation Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
⨯
Tracy Biaco,

Affiliation Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
⨯
Nikita Sedani,

Affiliation Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
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Jonathan Zou,

Affiliation Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
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Phillip Stashenko,

Affiliations Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
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Margaret J. Duncan,

Affiliation Department of Microbiology, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America
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Antonio Campos-Neto,

Affiliations Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
⨯
Mark J. Cayabyab

* E-mail: mcayabyab@forsyth.org

Affiliations Global Infectious Disease Research Center and the Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, Massachusetts, United States of America, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
⨯

Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance

Emily Xie,
Abhiroop Kotha,
Tracy Biaco,
Nikita Sedani,
Jonathan Zou,
Phillip Stashenko,
Margaret J. Duncan,
Antonio Campos-Neto,
Mark J. Cayabyab

Published: November 30, 2015
https://doi.org/10.1371/journal.pone.0143422

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