Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice

Kotaro Kumagai; Kazuaki Tabu; Fumisato Sasaki; Yoichiro Takami; Yuko Morinaga; Seiichi Mawatari; Shinichi Hashimoto; Shiroh Tanoue; Shuji Kanmura; Tsutomu Tamai; Akihiro Moriuchi; Hirofumi Uto; Hirohito Tsubouchi; Akio Ido

doi:10.1371/journal.pone.0143413

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Peer-reviewed

Research Article

Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice

Kotaro Kumagai ,

* E-mail: kumakou@m2.kufm.kagoshima-u.ac.jp

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Kazuaki Tabu,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Fumisato Sasaki,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Yoichiro Takami,

Affiliation Pharmaceutical Care and Health Sciences, School of Pharmacy, Shujitsu University, Okayama, Japan
⨯
Yuko Morinaga,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Seiichi Mawatari,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Shinichi Hashimoto,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Shiroh Tanoue,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Shuji Kanmura,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Tsutomu Tamai,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Akihiro Moriuchi,

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Hirofumi Uto,

Affiliations Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Center for Digestive and Liver diseases, Miyazaki Medical Center Hospital, Miyazaki, Japan
⨯
Hirohito Tsubouchi,

Affiliation Kagoshima City Hospital, Kagoshima, Japan
⨯
Akio Ido

Affiliation Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯

Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice

Kotaro Kumagai,
Kazuaki Tabu,
Fumisato Sasaki,
Yoichiro Takami,
Yuko Morinaga,
Seiichi Mawatari,
Shinichi Hashimoto,
Shiroh Tanoue,
Shuji Kanmura,
Tsutomu Tamai

Published: November 23, 2015
https://doi.org/10.1371/journal.pone.0143413

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