CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Minyan Li; Rui Huang; Xue Jiang; Yuxi Chen; Zhen Zhang; Xiya Zhang; Puping Liang; Shaoquan Zhan; Shanbo Cao; Zhou Songyang; Junjiu Huang

doi:10.1371/journal.pone.0143148

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Peer-reviewed

Research Article

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Minyan Li ,

Contributed equally to this work with: Minyan Li, Rui Huang

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Rui Huang ,

Contributed equally to this work with: Minyan Li, Rui Huang

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Xue Jiang,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Yuxi Chen,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Zhen Zhang,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Xiya Zhang,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Puping Liang,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Shaoquan Zhan,

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Reproductive Medicine of Guangdong Province, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Shanbo Cao,

Affiliation Key Laboratory of Reproductive Medicine of Guangdong Province, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Zhou Songyang ,

* E-mail: hjunjiu@mail.sysu.edu.cn (JJH); songyanz@mail.sysu.edu.cn (ZSY)

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
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Junjiu Huang

* E-mail: hjunjiu@mail.sysu.edu.cn (JJH); songyanz@mail.sysu.edu.cn (ZSY)

Affiliations Guangdong Province Key Laboratory of Reproductive Medicine, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, State Key Laboratory of Biocontrol, Institute of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
⨯

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Minyan Li,
Rui Huang,
Xue Jiang,
Yuxi Chen,
Zhen Zhang,
Xiya Zhang,
Puping Liang,
Shaoquan Zhan,
Shanbo Cao,
Zhou Songyang

Published: November 24, 2015
https://doi.org/10.1371/journal.pone.0143148

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