Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency

Luiz H. Araujo; Cynthia Timmers; Konstantin Shilo; Weiqiang Zhao; Jianying Zhang; Lianbo Yu; Thanemozhi G. Natarajan; Clinton J. Miller; Ayse Selen Yilmaz; Tom Liu; Joseph Amann; José Roberto Lapa e Silva; Carlos Gil Ferreira; David P. Carbone

doi:10.1371/journal.pone.0143092

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Open Access

Peer-reviewed

Research Article

Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency

Luiz H. Araujo,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Cynthia Timmers,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Konstantin Shilo,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Weiqiang Zhao,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Jianying Zhang,

Affiliation Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Lianbo Yu,

Affiliation Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Thanemozhi G. Natarajan,

Affiliation GenomOncology, Cleveland, Ohio, 44145, United States of America
⨯
Clinton J. Miller,

Affiliation GenomOncology, Cleveland, Ohio, 44145, United States of America
⨯
Ayse Selen Yilmaz,

Affiliations James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, 43210, United States of America, Biomedical Informatics Shared Resource, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Tom Liu,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
Joseph Amann,

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯
José Roberto Lapa e Silva,

Affiliation Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Carlos Gil Ferreira,

Affiliation Brazilian National Cancer Institute, Rio de Janeiro, Brazil
⨯
David P. Carbone

* E-mail: david.carbone@osumc.edu

Affiliation James Thoracic Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
⨯

Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency

Luiz H. Araujo,
Cynthia Timmers,
Konstantin Shilo,
Weiqiang Zhao,
Jianying Zhang,
Lianbo Yu,
Thanemozhi G. Natarajan,
Clinton J. Miller,
Ayse Selen Yilmaz,
Tom Liu

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0143092

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Non-small cell lung cancer
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DNA sequencing
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Gene sequencing
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Head and neck cancers
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Lung and intrathoracic tumors
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