First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

Open Access

Peer-reviewed

Research Article

Joshua E. Allen,

Affiliation Oncoceutics, Inc., Philadelphia, Pennsylvania, 19103, United States of America
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Roslyn Crowder,

Affiliation Department of Biology, Stetson University, DeLand, Florida, 32723, United States of America
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Wafik S. El-Deiry

* E-mail: wafik.eldeiry@gmail.com

Affiliation Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
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Cancer treatment
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Lung and intrathoracic tumors
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Cancers and neoplasms
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Apoptosis
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Cell death
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