A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia

• Yung-Li Yang ,

  Contributed equally to this work with: Yung-Li Yang, Ching-Tzu Yen

  Affiliations Departments of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, Departments of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Ching-Tzu Yen ,

  Contributed equally to this work with: Yung-Li Yang, Ching-Tzu Yen

  Affiliation Departments of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Chen-Hsueh Pai,

  Affiliation Departments of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Hsuan-Yu Chen,

  Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

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• Sung-Liang Yu,

  Affiliation Departments of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Chien-Yu Lin,

  Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

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• Chung-Yi Hu,

  Affiliation Departments of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shiann-Tarng Jou,

  Affiliation Departments of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Dong-Tsamn Lin,

  Affiliations Departments of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, Departments of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shu-Rung Lin ,

  * E-mail: shurung@cycu.edu.tw (SRL); mtshuwha@ntu.edu.tw (SWL)

  ¶‡ These authors also contributed equally to this work.

  Affiliations Department of Bioscience Technology, College of Science, Chung-Yuan Christian University, Taoyuan, Taiwan, Center for Nanotechnology and Center for Biomedical Technology, College of Science, Chung-Yuan Christian University, Taoyuan, Taiwan

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• Shu-Wha Lin

  * E-mail: shurung@cycu.edu.tw (SRL); mtshuwha@ntu.edu.tw (SWL)

  ¶‡ These authors also contributed equally to this work.

  Affiliation Departments of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

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