Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation

Hu Peng; Yugang Zhuang; Mark C. Harbeck; Donghong He; Lishi Xie; Weiguo Chen

doi:10.1371/journal.pone.0142854

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Peer-reviewed

Research Article

Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation

Hu Peng ,

Contributed equally to this work with: Hu Peng, Yugang Zhuang

Affiliations Department of Emergency Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China, Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯
Yugang Zhuang ,

Contributed equally to this work with: Hu Peng, Yugang Zhuang

Affiliations Department of Emergency Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China, Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯
Mark C. Harbeck,

Affiliation Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯
Donghong He,

Affiliation Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯
Lishi Xie,

Affiliation Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯
Weiguo Chen

* E-mail: weiguo@uic.edu

Affiliations Department of Emergency Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China, Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, United States
⨯

Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation

Hu Peng,
Yugang Zhuang,
Mark C. Harbeck,
Donghong He,
Lishi Xie,
Weiguo Chen

Published: November 11, 2015
https://doi.org/10.1371/journal.pone.0142854

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Phosphorylation
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HEK 293 cells
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Serine
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Nitric oxide
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Superoxides
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MTT assay
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Oxidation
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