Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

Neil L. Spector; Faith C. Robertson; Sarah Bacus; Kimberly Blackwell; Deborah A. Smith; Kelli Glenn; Leanne Cartee; Jennifer Harris; Carie L. Kimbrough; Mark Gittelman; Eli Avisar; Peter Beitsch; Kevin M. Koch

doi:10.1371/journal.pone.0142845

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Open Access

Peer-reviewed

Research Article

Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

Neil L. Spector ,

Contributed equally to this work with: Neil L. Spector, Faith C. Robertson

* E-mail: Neil.Spector@duke.edu

Affiliation Department of Medicine, Duke Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Faith C. Robertson ,

Contributed equally to this work with: Neil L. Spector, Faith C. Robertson

Affiliation Department of Medicine, Duke Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Sarah Bacus,

Affiliation Targeted Molecular Diagnostics/Quintiles, Westmont, Illinois, United States of America
⨯
Kimberly Blackwell,

Affiliation Department of Medicine, Duke Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Deborah A. Smith,

Current address: PAREXEL International, Durham, North Carolina, United States of America

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Kelli Glenn,

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Leanne Cartee,

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Jennifer Harris,

Affiliation Pivot Oncology Consulting, Durham, North Carolina, United States of America
⨯
Carie L. Kimbrough,

Affiliation PAREXEL International, Durham, North Carolina, United States of America
⨯
Mark Gittelman,

Affiliation Breast Cancer Specialists, Allentown, Pennsylvania, United States of America
⨯
Eli Avisar,

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Peter Beitsch,

Affiliation Dallas Surgical Group, Dallas, Texas, United States of America
⨯
Kevin M. Koch

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯

Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

Neil L. Spector,
Faith C. Robertson,
Sarah Bacus,
Kimberly Blackwell,
Deborah A. Smith,
Kelli Glenn,
Leanne Cartee,
Jennifer Harris,
Carie L. Kimbrough,
Mark Gittelman

Published: November 16, 2015
https://doi.org/10.1371/journal.pone.0142845

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