Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

Hideki Yagi; Bisei Ohkawara; Hiroaki Nakashima; Kenyu Ito; Mikito Tsushima; Hisao Ishii; Kimitoshi Noto; Kyotaro Ohta; Akio Masuda; Shiro Imagama; Naoki Ishiguro; Kinji Ohno

doi:10.1371/journal.pone.0142786

Loading metrics

Open Access

Peer-reviewed

Research Article

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

Hideki Yagi,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Bisei Ohkawara,

Affiliation Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Hiroaki Nakashima,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Kenyu Ito,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Mikito Tsushima,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Hisao Ishii,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Hand Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Kimitoshi Noto,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Hand Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Kyotaro Ohta,

Affiliations Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Akio Masuda,

Affiliation Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Shiro Imagama,

Affiliation Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Naoki Ishiguro,

Affiliation Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯
Kinji Ohno

* E-mail: ohnok@med.nagoya-u.ac.jp

Affiliation Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
⨯

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

Hideki Yagi,
Bisei Ohkawara,
Hiroaki Nakashima,
Kenyu Ito,
Mikito Tsushima,
Hisao Ishii,
Kimitoshi Noto,
Kyotaro Ohta,
Akio Masuda,
Shiro Imagama

Published: November 16, 2015
https://doi.org/10.1371/journal.pone.0142786

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Motor neurons
Is the Subject Area "Motor neurons" applicable to this article?

Thanks for your feedback.
Neurites
Is the Subject Area "Neurites" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Sciatic nerves
Is the Subject Area "Sciatic nerves" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Nerve regeneration
Is the Subject Area "Nerve regeneration" applicable to this article?

Thanks for your feedback.
Neuronal differentiation
Is the Subject Area "Neuronal differentiation" applicable to this article?

Thanks for your feedback.
Axons
Is the Subject Area "Axons" applicable to this article?

Thanks for your feedback.