Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway

Wei Liu; Chao Xu; Hongyan Zhao; Pengpeng Xia; Ruilong Song; Jianhong Gu; Xuezhong Liu; Jianchun Bian; Yan Yuan; Zongping Liu

doi:10.1371/journal.pone.0142519

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Open Access

Peer-reviewed

Research Article

Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway

Wei Liu ,

Contributed equally to this work with: Wei Liu, Chao Xu

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Chao Xu ,

Contributed equally to this work with: Wei Liu, Chao Xu

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Hongyan Zhao,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Pengpeng Xia,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Ruilong Song,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Jianhong Gu,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Xuezhong Liu,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Jianchun Bian,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Yan Yuan,

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯
Zongping Liu

* E-mail: liuzongping@yzu.edu.cn

Affiliations College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China
⨯

Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway

Wei Liu,
Chao Xu,
Hongyan Zhao,
Pengpeng Xia,
Ruilong Song,
Jianhong Gu,
Xuezhong Liu,
Jianchun Bian,
Yan Yuan,
Zongping Liu

Published: November 16, 2015
https://doi.org/10.1371/journal.pone.0142519

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Apoptosis
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Osteoclasts
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Mitochondria
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Immunoprecipitation
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Precursor cells
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