Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Luca Gambini; Luca Rizzi; Alessandro Pedretti; Orazio Taglialatela-Scafati; Mario Carucci; Andrea Pancotti; Corinna Galli; Martin Read; Emanuele Giurisato; Sergio Romeo; Ilaria Russo

doi:10.1371/journal.pone.0142509

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Peer-reviewed

Research Article

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Luca Gambini ,

Contributed equally to this work with: Luca Gambini, Ilaria Russo

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Luca Rizzi,

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Alessandro Pedretti,

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Orazio Taglialatela-Scafati,

Affiliation Department of Chemistry of Natural Substances, Faculty of Pharmacy, Università di Napoli "Federico II", Naples, Italy
⨯
Mario Carucci,

Affiliation Department of Experimental Medicine and Biochemical Sciences, Università degli Studi di Perugia, Perugia, Italy
⨯
Andrea Pancotti,

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Corinna Galli,

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Martin Read,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Emanuele Giurisato,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Sergio Romeo,

Affiliation Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy
⨯
Ilaria Russo

Contributed equally to this work with: Luca Gambini, Ilaria Russo

* E-mail: ilaria.russo@manchester.ac.uk

Affiliations Department of Experimental Medicine and Biochemical Sciences, Università degli Studi di Perugia, Perugia, Italy, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Luca Gambini,
Luca Rizzi,
Alessandro Pedretti,
Orazio Taglialatela-Scafati,
Mario Carucci,
Andrea Pancotti,
Corinna Galli,
Martin Read,
Emanuele Giurisato,
Sergio Romeo

Published: November 13, 2015
https://doi.org/10.1371/journal.pone.0142509

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