Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models

Karolina Pytka; Anna Partyka; Magdalena Jastrzębska-Więsek; Agata Siwek; Monika Głuch-Lutwin; Barbara Mordyl; Grzegorz Kazek; Anna Rapacz; Adrian Olczyk; Adam Gałuszka; Marian Błachuta; Anna Waszkielewicz; Henryk Marona; Jacek Sapa; Barbara Filipek; Anna Wesołowska

doi:10.1371/journal.pone.0142499

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Open Access

Peer-reviewed

Research Article

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT_1A and 5-HT₇ Antagonists in Animal Models

Karolina Pytka ,

* E-mail: karolina.pytka@uj.edu.pl

Affiliation Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Anna Partyka,

Affiliation Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Magdalena Jastrzębska-Więsek,

Affiliation Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Agata Siwek,

Affiliation Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Monika Głuch-Lutwin,

Affiliation Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Barbara Mordyl,

Affiliation Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Grzegorz Kazek,

Affiliation Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Anna Rapacz,

Affiliation Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Adrian Olczyk,

Affiliation Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44–100, Gliwice, Poland
⨯
Adam Gałuszka,

Affiliation Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44–100, Gliwice, Poland
⨯
Marian Błachuta,

Affiliation Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44–100, Gliwice, Poland
⨯
Anna Waszkielewicz,

Affiliation Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Henryk Marona,

Affiliation Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Jacek Sapa,

Affiliation Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
Barbara Filipek,

Affiliation Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
[ ... ],
Anna Wesołowska

Affiliation Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30–688, Krakow, Poland
⨯
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Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT_1A and 5-HT₇ Antagonists in Animal Models

Karolina Pytka,
Anna Partyka,
Magdalena Jastrzębska-Więsek,
Agata Siwek,
Monika Głuch-Lutwin,
Barbara Mordyl,
Grzegorz Kazek,
Anna Rapacz,
Adrian Olczyk,
Adam Gałuszka

Published: November 10, 2015
https://doi.org/10.1371/journal.pone.0142499

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