Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

Vijayasree V. Giridharan; Rajarajan A. Thandavarayan; Somasundaram Arumugam; Makoto Mizuno; Hiroyuki Nawa; Kenji Suzuki; Kam M. Ko; Prasanna Krishnamurthy; Kenichi Watanabe; Tetsuya Konishi

doi:10.1371/journal.pone.0142483

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Research Article

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

Vijayasree V. Giridharan,

Affiliation J.K.K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu, India
⨯
Rajarajan A. Thandavarayan ,

Contributed equally to this work with: Rajarajan A. Thandavarayan, Tetsuya Konishi

* E-mail: atrajarajan@gmail.com (RAT); konishi@nupals.ac.jp (TK)

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Somasundaram Arumugam,

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy & Applied Life Sciences (NUPALS), Niigata City, Japan
⨯
Makoto Mizuno,

Affiliation Division of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
⨯
Hiroyuki Nawa,

Affiliation Division of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
⨯
Kenji Suzuki,

Affiliation Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Kam M. Ko,

Affiliation Section of Biochemistry and Cell biology, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
⨯
Prasanna Krishnamurthy,

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Kenichi Watanabe,

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy & Applied Life Sciences (NUPALS), Niigata City, Japan
⨯
Tetsuya Konishi

Contributed equally to this work with: Rajarajan A. Thandavarayan, Tetsuya Konishi

* E-mail: atrajarajan@gmail.com (RAT); konishi@nupals.ac.jp (TK)

Affiliation Basic studies on second generation functional foods, NUPALS, NUPALS Liaison R/D promotion division, Niigata, Japan, Changchun University of Chinese Medicine, Changchun, RP China
⨯

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

Vijayasree V. Giridharan,
Rajarajan A. Thandavarayan,
Somasundaram Arumugam,
Makoto Mizuno,
Hiroyuki Nawa,
Kenji Suzuki,
Kam M. Ko,
Prasanna Krishnamurthy,
Kenichi Watanabe,
Tetsuya Konishi

Published: November 10, 2015
https://doi.org/10.1371/journal.pone.0142483

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