Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

Eugenie Poirot; Eric Vittinghoff; Deus Ishengoma; Michael Alifrangis; Ilona Carneiro; Ramadhan Hashim; Vito Baraka; Jacklin Mosha; Samwel Gesase; Daniel Chandramohan; Roland Gosling

doi:10.1371/journal.pone.0142414

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Peer-reviewed

Research Article

Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

Eugenie Poirot ,

* E-mail: Eugenie.poirot@ucsf.edu

Affiliations Global Health Group, University of California San Francisco, San Francisco, California, United States of America, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
⨯
Eric Vittinghoff,

Affiliation Global Health Group, University of California San Francisco, San Francisco, California, United States of America
⨯
Deus Ishengoma,

Affiliation Tanga Medical Research Centre, National Institute for Medical Research, Tanga, United Republic of Tanzania
⨯
Michael Alifrangis,

Affiliations Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, Department of Infectious Diseases, National University Hospital (Rigshospitalet), Copenhagen, Denmark
⨯
Ilona Carneiro,

Affiliation Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Ramadhan Hashim,

Affiliation Mwanza Interventions Trial Unit, National Institute for Medical Research, Mwanza, United Republic of Tanzania
⨯
Vito Baraka,

Affiliations Tanga Medical Research Centre, National Institute for Medical Research, Tanga, United Republic of Tanzania, International Health Unit, Department of Epidemiology, University of Antwerp, Antwerp, Belgium
⨯
Jacklin Mosha,

Affiliation Mwanza Interventions Trial Unit, National Institute for Medical Research, Mwanza, United Republic of Tanzania
⨯
Samwel Gesase,

Affiliation Tanga Medical Research Centre, National Institute for Medical Research, Tanga, United Republic of Tanzania
⨯
Daniel Chandramohan,

Affiliation Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Roland Gosling

Affiliations Global Health Group, University of California San Francisco, San Francisco, California, United States of America, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
⨯

Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

Eugenie Poirot,
Eric Vittinghoff,
Deus Ishengoma,
Michael Alifrangis,
Ilona Carneiro,
Ramadhan Hashim,
Vito Baraka,
Jacklin Mosha,
Samwel Gesase,
Daniel Chandramohan

Published: November 23, 2015
https://doi.org/10.1371/journal.pone.0142414

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Hemoglobin
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Glucose-6-phosphate dehydrogenase deficiency
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Antimalarials
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Malaria
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Infants
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Heterozygosity
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Medical risk factors
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Adverse events
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