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Open Access

Peer-reviewed

Research Article

Interstitial Fluid Flow Increases Hepatocellular Carcinoma Cell Invasion through CXCR4/CXCL12 and MEK/ERK Signaling

Arpit D. Shah ,

Contributed equally to this work with: Arpit D. Shah, Michael J. Bouchard, Adrian C. Shieh

Affiliation School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, United States of America
⨯
Michael J. Bouchard ,

Contributed equally to this work with: Arpit D. Shah, Michael J. Bouchard, Adrian C. Shieh

Affiliation Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Adrian C. Shieh

Contributed equally to this work with: Arpit D. Shah, Michael J. Bouchard, Adrian C. Shieh

* E-mail: Adrian.C.Shieh@drexel.edu

Affiliation School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, United States of America
⨯

Interstitial Fluid Flow Increases Hepatocellular Carcinoma Cell Invasion through CXCR4/CXCL12 and MEK/ERK Signaling

Arpit D. Shah,
Michael J. Bouchard,
Adrian C. Shieh

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Published: November 11, 2015
https://doi.org/10.1371/journal.pone.0142337

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Hepatocellular carcinoma
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Cancer treatment
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Fluid flow
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Chemotaxis
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Interstitial fluid
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ERK signaling cascade
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Breast cancer
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Lung and intrathoracic tumors
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