Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle

Gillian S. Dean; Derek Clifford; Adam O. Whelan; Elma Z. Tchilian; Peter C. L. Beverley; Francisco J. Salguero; Zhou Xing; Hans M. Vordermeier; Bernardo Villarreal-Ramos

doi:10.1371/journal.pone.0142270

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Peer-reviewed

Research Article

Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle

Gillian S. Dean,

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯
Derek Clifford,

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯
Adam O. Whelan,

Current address: Microbiology, Defence Science and Technology Laboratory, Biomedical Sciences, Building 7a, Dstl, Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯
Elma Z. Tchilian,

Current address: The Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, United Kingdom

Affiliation The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, United Kingdom
⨯
Peter C. L. Beverley,

Current address: Respiratory Infection and Airway Disease Infection Section, National Heart & Lung Institute (NHLI), Imperial College London, London, United Kingdom

Affiliation The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, United Kingdom
⨯
Francisco J. Salguero,

Current address: School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7TE, United Kingdom

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯
Zhou Xing,

Affiliation McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
⨯
Hans M. Vordermeier,

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯
Bernardo Villarreal-Ramos

* E-mail: Bernardo.Villarreal-Ramos@apha.gsi.gov.uk

Affiliation TB Research Group, APHA Weybridge, Woodham Lane, New Haw, KT15 3NB, Surrey, United Kingdom
⨯

Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle

Gillian S. Dean,
Derek Clifford,
Adam O. Whelan,
Elma Z. Tchilian,
Peter C. L. Beverley,
Francisco J. Salguero,
Zhou Xing,
Hans M. Vordermeier,
Bernardo Villarreal-Ramos

Published: November 6, 2015
https://doi.org/10.1371/journal.pone.0142270

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Mycobacterium bovis
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Cattle
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