Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes; Natalia Mendes Schöwe; Karla Cristina Monteiro-Silva; Ticiana Baraldi-Tornisielo; Suzzanna Ingryd Gonçalves Souza; Janaina Balthazar; Marilia Silva Albuquerque; Ariadiny Lima Caetano; Tania Araujo Viel; Hudson Sousa Buck

doi:10.1371/journal.pone.0142267

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Peer-reviewed

Research Article

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes ,

Contributed equally to this work with: Marielza Andrade Nunes, Natalia Mendes Schöwe

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯
Natalia Mendes Schöwe ,

Contributed equally to this work with: Marielza Andrade Nunes, Natalia Mendes Schöwe

Affiliations Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯
Karla Cristina Monteiro-Silva,

Affiliation Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil
⨯
Ticiana Baraldi-Tornisielo,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Suzzanna Ingryd Gonçalves Souza,

Affiliation Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil
⨯
Janaina Balthazar,

Affiliation Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil
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Marilia Silva Albuquerque,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Ariadiny Lima Caetano,

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯
Tania Araujo Viel,

Affiliations Graduation Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil, School of Arts, Sciences and Humanities, Universidade de São Paulo, Av. Arlindo Bettio, 1000, São Paulo, SP 03828–080, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
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Hudson Sousa Buck

* E-mail: hudson.buck@fcmsantacasasp.edu.br

Affiliations Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, R. Dr. Cesario Motta Junior, 61, 11° andar, São Paulo, SP 01221–020, Brazil, Research Group on Neuropharmacology of Aging—ReGNA, Sao Paulo, Brazil
⨯

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

Marielza Andrade Nunes,
Natalia Mendes Schöwe,
Karla Cristina Monteiro-Silva,
Ticiana Baraldi-Tornisielo,
Suzzanna Ingryd Gonçalves Souza,
Janaina Balthazar,
Marilia Silva Albuquerque,
Ariadiny Lima Caetano,
Tania Araujo Viel,
Hudson Sousa Buck

Published: November 25, 2015
https://doi.org/10.1371/journal.pone.0142267

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27 Nov 2015
14:51 GMT
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Typing errors in the manuscript. Posted by hudsonbuck on 27 Nov 2015 at 14:51 GMT

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