Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

Xiaoming Li; Min Xu; Fei Wang; Yong Ji; W. Sean DavidsoN; Zongfang Li; Patrick Tso

doi:10.1371/journal.pone.0142098

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Peer-reviewed

Research Article

Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

Xiaoming Li,

Affiliations National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, 157 W 5th Rd, Xincheng, Xi'an, Shaanxi, 710004, China, Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯
Min Xu,

Affiliation Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯
Fei Wang,

Affiliation Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯
Yong Ji,

Affiliation Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯
W. Sean DavidsoN,

Affiliation Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯
Zongfang Li ,

* E-mail: Patrick_Tso@yeah.net (PT); lizhongfangbm@163.com (ZL)

Affiliation National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, 157 W 5th Rd, Xincheng, Xi'an, Shaanxi, 710004, China
⨯
Patrick Tso

* E-mail: Patrick_Tso@yeah.net (PT); lizhongfangbm@163.com (ZL)

Affiliation Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E. Galbraith Road, Cincinnati, 45237–0507, United States of America
⨯

Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

Xiaoming Li,
Min Xu,
Fei Wang,
Yong Ji,
W. Sean DavidsoN,
Zongfang Li,
Patrick Tso

Published: November 10, 2015
https://doi.org/10.1371/journal.pone.0142098

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Transfection
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Gene expression
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