Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

Alexandre Amlie-Wolf; Paul Ryvkin; Rui Tong; Isabelle Dragomir; EunRan Suh; Yan Xu; Vivianna M. Van Deerlin; Brian D. Gregory; Linda K. Kwong; John Q. Trojanowski; Virginia M.-Y. Lee; Li-San Wang; Edward B. Lee

doi:10.1371/journal.pone.0141836

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Peer-reviewed

Research Article

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

Alexandre Amlie-Wolf,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Paul Ryvkin,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Rui Tong,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Isabelle Dragomir,

Affiliation Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
EunRan Suh,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Yan Xu,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Vivianna M. Van Deerlin,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Brian D. Gregory,

Affiliation Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Linda K. Kwong,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
John Q. Trojanowski,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Virginia M.-Y. Lee,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Li-San Wang,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Edward B. Lee

* E-mail: edward.lee@uphs.upenn.edu

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

Alexandre Amlie-Wolf,
Paul Ryvkin,
Rui Tong,
Isabelle Dragomir,
EunRan Suh,
Yan Xu,
Vivianna M. Van Deerlin,
Brian D. Gregory,
Linda K. Kwong,
John Q. Trojanowski

Published: October 28, 2015
https://doi.org/10.1371/journal.pone.0141836

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Histones
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Transcriptome analysis
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RNA sequencing
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3' UTR
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