Hypoxia Induces a Prothrombotic State Independently of the Physical Activity

Marisa Ninivaggi; Marieke de Laat; Marcus M. D. Lancé; Cécile H. Kicken; Leonie Pelkmans; Saartje Bloemen; Marlou L. Dirks; Luc J. C. van Loon; José W. P. Govers-Riemslag; Theo Lindhout; Joke Konings; Bas de Laat

doi:10.1371/journal.pone.0141797

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Open Access

Peer-reviewed

Research Article

Hypoxia Induces a Prothrombotic State Independently of the Physical Activity

Marisa Ninivaggi,

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marieke de Laat,

Affiliation Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marcus M. D. Lancé,

Affiliation Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Cécile H. Kicken,

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Leonie Pelkmans,

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Saartje Bloemen,

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marlou L. Dirks,

Affiliation Department of NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Luc J. C. van Loon,

Affiliation Department of NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
José W. P. Govers-Riemslag,

Affiliation Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Theo Lindhout,

Affiliation Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Joke Konings,

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Bas de Laat

* E-mail: b.delaat@thrombin.com

Affiliations Department of Synapse bv, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Biochemistry, Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Hypoxia Induces a Prothrombotic State Independently of the Physical Activity

Marisa Ninivaggi,
Marieke de Laat,
Marcus M. D. Lancé,
Cécile H. Kicken,
Leonie Pelkmans,
Saartje Bloemen,
Marlou L. Dirks,
Luc J. C. van Loon,
José W. P. Govers-Riemslag,
Theo Lindhout

Published: October 30, 2015
https://doi.org/10.1371/journal.pone.0141797

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